CICA PDRN

CICA PDRN is a modern, premium regenerative ingredient developed in South Korea, one of the global centers of cosmetic innovation. The formula was designed to simultaneously deliver the soothing benefits of Centella asiatica and the high regenerative activity of sodium DNA.

This raw material contains water, Centella asiatica extract (5%), Sodium DNA (0.0005% / 5 ppm), and 1,2-hexanediol as a mild humectant and stabilizing agent. This composition provides synergistic pro-regenerative, anti-inflammatory, and skin-healing effects.

Properties and mechanism of action of CICA PDRN

1. Tissue regeneration and healing of damage

PDRN is a 65–325 kDa DNA polymer that activates the adenosine A2A receptor present on the surface of skin cells. Stimulation of this receptor triggers repair processes, accelerates fibroblast proliferation, and supports natural tissue regeneration.

The ingredient also has an anti-ischemic effect, supports angiogenesis and stimulates collagen synthesis , which is important in anti-aging products and after dermatological treatments.

2. Anti-inflammatory and soothing effect

Centella asiatica is rich in triterpenoids such as asiaticoside and madecassoside , known for their strong anti-inflammatory properties. Combined with PDRN, the raw material effectively reduces inflammatory responses and helps soothe irritations caused by environmental stress, UV radiation, and cosmetic treatments.

Reducing the expression of inflammatory markers (NF-κB, IL-1, TNF-α, COX-2) and reducing MMP activity translates into protecting collagen from degradation and improving skin elasticity.

3. Improving skin elasticity, hydration and structure

This ingredient improves skin hydration thanks to the presence of Centella asiatica extract and humectant components . It also stimulates collagen and elastin synthesis by increasing SOD activity and reducing NADPH oxidase activity, while also reducing melanin synthesis.

The effect of using the ingredient is increased skin elasticity, smoothing of fine wrinkles and reducing the visibility of pores.

4. Supports the reduction of scars and discoloration

Thanks to its regenerative properties and inflammatory modulation, CICA PDRN is used in products that help reduce the appearance of scars, post-inflammatory discoloration, and acne scars . This mechanism results from the regulation of MITF expression and tyrosinase activity – key components of skin pigmentation processes.

Application of CICA PDRN in cosmetics

CICA PDRN is a multifunctional ingredient recommended for products:

• regenerative cosmetics – barrier rebuilding serums, repair creams, treatments after dermatological procedures,
• anti-aging cosmetics – formulas that reduce wrinkles, improve firmness and elasticity,
• cosmetics for sensitive skin – soothing creams and emulsions, products that soothe redness,
• cosmetics for the care of problematic skin – supporting the healing of lesions, reducing scars and discolorations,
• dermatological and professional products – post-treatment masks, ampoules, products for office use,
• body care – regenerating balms, products for irritated skin.